1. Monthly, daily and hourly figures are estimates only, based on total scans per year of 10,531,410 in 2019. Data on file at Align Technology, as of January 29, 2020.
    2. Retrospective data evaluation and quantitative analysis completed by Dr. MacKay, University of Memphis. 495 Orthodontic practices worldwide. Accepted for publication Journal of Clinical Dentistry. Study sponsored by Align Technology.
    3. Valuation based on assumed €4,853 Invisalign Case Fee. Case fee varies based on individual treatment needs. Data on file at Align Technology as of December 17, 2018.
    4. Retrospective data evaluation and quantitative analysis completed by Dr. MacKay, University of Memphis. 1,871 GP and Orthodontic practices worldwide. Orthodontic segment increase 18.71%/12 months and 17.26%/24 months. GP segment increase 10.6%/12 months and .16%/24 months. Accepted for publication Journal of Clinical Dentistry. Study sponsored by Align Technology.
    5. At the independent discretion of the qualified healthcare professional
    6. Available on iTero Element™ 5D Plus software configuration. Disabled with Lite software configuration.
    7. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I’ve diagnosed a higher number of interproximal caries above the gingiva, on my patients at my practice”. Data on file at Align Technology, as of November 15, 2019.
    8. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I experienced an increase in treated interproximal caries cases on my patients at my practice”, and then asked to estimate the average increase in revenue for the practice. Data on file at Align Technology, as of November 15, 2019.
    9. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I experienced an increase in the number of accepted caries treatments by my patients at my practice”, and then asked to estimate the average increase. Data on file at Align Technology, as of November 15, 2019.
    10. Unless otherwise specified, all comparisons are relative to previous generation iTero Element™ scanners
    11. On average, with the iTero™ Plus series as compared to the iTero Element™ 2 and iTero Element™ 5D, and based on scan processing time comparison of 40 Invisalign scans and 40 restorative scans with 3 prep teeth processed by the iTero Element™ 2/iTero Element™ 5D computing units and the iTero Element™ Plus series computing unit.
    12. Monthly, daily and hourly figures are estimates only, based on total scans per year of 10,531,410 in 2019. Data on file at Align Technology, as of January 29, 2020.
    13. Data on file at Align Technology, as of June 30, 2021
    14. Accuracy defined as a combination of trueness and precision tested on different substrates, under different lighting conditions, for crown preparation and full-arch scanning. Based on the results of 12 peer-reviewed papers 2018-2020. Data on file at Align Technology, as of November 20, 2020.
    15. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I’ve diagnosed a higher number of interproximal caries above the gingiva, on my patients at my practice”. Data on file at Align Technology, as of November 15, 2019.
    16. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I experienced an increase in treated interproximal caries cases on my patients at my practice”, and then asked to estimate the average increase in revenue for the practice. Data on file at Align Technology, as of November 15, 2019.
    17. Based on a survey in May of 2019 of n = 15 practitioners who participated in a global limited market release, working with iTero Element™ 5D for an average period of 6 months, representing both GPs and Orthos in CAN, EU and APAC, who were presented with a level of agreement scale from strongly agree to strongly disagree with the following statements: “Incorporating the iTero Element™ 5D scanner into my current diagnostic protocol, I experienced an increase in the number of accepted caries treatments by my patients at my practice”, and then asked to estimate the average increase. Data on file at Align Technology, as of November 15, 2019.
    18. Study sponsored by Align Technology. Retrospective data evaluation and quantitative analysis completed by Dr. Michael MacKay, University of Memphis, 2018. 1,115 GP doctors (countries included: AU, AT, BE, BM, CA, DE, DK, FR, HK, IT, KR, LI, LU, NL, NZ, PL, PR, RU, SG, ES, SE, CH, TW, TH, GB, US, VN) with low-volume Invisalign usage (defined as 5 or fewer Invisalign receipts in the 12 months prior to acquiring the iTero™ scanner) who use an iTero Element™ scanner (at 12 months n = 1,115, at 24 months n = 363 and at 36 months n = 135)
    19. MSRP for iTero Element™ = €25,999, iTero Element™ 2 = €30,999, iTero Element Flex = €26,999. Study based on use of iTero Element™ model only. Claim based on extrapolation of results to include iTero Element™ 2 and iTero Element™ Flex models which utilize the same iTero Element Software.
    20. Valuation based on assumed €4,853 Invisalign Case Fee. Case fee varies based on individual treatment needs. Data on file at Align Technology as of December 17, 2018.
    21. Based on 10,000 scans, mean transfer time, defined as the time between the practice sending the iTero scan and the dental laboratory receiving it, is 4.6min. May vary based on internet connection. Data on file at Align Technology, as of February 12, 2020.
    22. Available on the iTero Element™ 5D imaging systems, which include the iTero Element™ 5D and iTero Element™ 5D Plus Series imaging system.​
    * iTero Element™ scanner model(s) may not be available in all markets. Please consult with your local Align Technology office. The iTero Element™ Plus Series is currently available in European Union countries, Norway, Switzerland & United Kingdom. ​